Anti-Müllerian hormone serum concentrations of women with germlineBRCA1orBRCA2mutations
نویسندگان
چکیده
منابع مشابه
Increased anti-Müllerian hormone serum concentrations in prepubertal daughters of women with polycystic ovary syndrome.
CONTEXT Anti-Müllerian hormone (AMH) is produced by the granulosa cells and reflects follicular development. Adult women with polycystic ovary syndrome (PCOS) have increased levels of AMH associated with an excessive number of growing follicles. However, it is not known whether these abnormalities are present before the clinical onset of PCOS. OBJECTIVE Our objective was to investigate whethe...
متن کاملAnti-Müllerian hormone serum concentrations of women with germline BRCA1 or BRCA2 mutations
STUDY QUESTION Do women with ITALIC! BRCA1 or ITALIC! BRCA2 mutations have reduced ovarian reserve, as measured by circulating anti-Müllerian hormone (AMH) concentration? SUMMARY ANSWER Women with a germline mutation in ITALIC! BRCA1 have reduced ovarian reserve as measured by AMH. WHAT IS KNOWN ALREADY The DNA repair enzymes encoded by ITALIC! BRCA1 and ITALIC! BRCA2 are implicated in repr...
متن کاملAnti-Müllerian hormone concentrations in maternal serum during pregnancy.
BACKGROUND In females, anti-Müllerian hormone (AMH) is expressed only by the ovary. AMH is secreted by the granulosa cells of ovarian follicles and appears to regulate early follicle development. AMH is detected in serum from women of reproductive age and its levels vary slightly with the menstrual cycle, reaching the peak value in the late follicular phase. This study investigated serum AMH le...
متن کاملAnti-Müllerian hormone serum concentrations in normoovulatory and anovulatory women of reproductive age.
Anti-Müllerian hormone (AMH) concentrations correlate with the number of antral follicles as well as age and constitute an endocrine marker for ovarian aging. In normogonadotropic anovulatory infertile women [World Health Organization (WHO) class 2], the number of early antral follicles is usually increased. To investigate whether AMH concentrations are increased, serum levels in 128 WHO 2 wome...
متن کاملLive Birth Rate following Intrauterine Insemination in Women with Low or Very Low Level of Serum Anti-müllerian Hormone
Background: While anti-Müllerian hormone (AMH) level allows quantitative evaluation of ovarian reserve, its predictive value for live births following assisted reproductive technology cycles has remained controversial. The aim of the present study was to assess the importance of AMH in predicting live birth following intrauterine insemination (IUI) in the case of low or very lo...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2016
ISSN: 0268-1161,1460-2350
DOI: 10.1093/humrep/dew044